Key result
Genomic analysis of archival specimens indicates that the Norovirus GII.P4_GII.4 sequence likely resulted from a recombination event around 1980.
Genomic analysis suggests that the NoV GII.P4_GII.4 sequence emerged from a recombination event around 1980, ending the major prevalence of NoV GII.4.
May inform norovirus surveillance timelines; hypothesis-generating without practice implications.
This study aimed to analyze NoV GII.4 sequences from archival specimens obtained during 1975-1987 by comparing them with reference sequences. The first NoV GII.P4_GII.4 sequence was identified in 1980. NoV GII.4 collected in 1970 had a GII.P1_GII.4 sequence. These results indicate that the GII.P4_GII.4 sequence may be the result of a recombination that might have occurred around 1980. Amino acid substitutions based on this replacement were mainly accumulated in the NTPase, p22, and RdRp regions. The emergence of GII.P4_GII.4 sequence is considered to have ended the major prevalence of NoV GII.4. J. Med. Virol. 89:363-367, 2017.
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Mori et al. (2016) studied Norovirus GII.4. Genomic analysis vs. Reference sequences was evaluated on Evolutionary lineage and recombination events. Genomic analysis of archival specimens indicates that the Norovirus GII.P4_GII.4 sequence likely resulted from a recombination event around 1980.
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