Clinical and Experimental Studies on the Action of Prostaglandins and their Synthesis Inhibitors on Detrusor Muscle in vitro and in vivo

Summary Experiments on muscle strips have shown that prostaglandin is naturally produced by the detrusor, and acts to increase the tone and spontaneous activity. An intimate relation between acetylcholine and prostaglandin has been demonstrated. Therapeutic application of prostaglandins has been successful in the treatment of chronic retention in women. Upjohn Limited kindly supplied the prostaglandin E 2 . This work was supported by a grant from the Endowment Fund of St Thomas's Hospital, and the muscle strip experiments were carried out in the Department of Pharmacology.