Why the study?
Human parechoviruses can cause severe disease in adults, but their prevalence in adults may be much lower than in children and remains unclear.
Observational (n=6,175)
No
The prevalence of Human parechovirus in adults is very low (0.18%) compared to children, likely due to high seropositivity rates.
Rare adult detection supports seroprevalence-driven immunity; leaves open adult disease burden and surveillance needs.
Human parechoviruses (HPeV) of the species Parechovirus A are highly prevalent disease-causing pathogens in children worldwide. HPeVs are capable of causing severe disease in adults as well, but the prevalence in adults may be much lower. The aim of our present study was to determine the prevalence of HPeV in clinical samples from adults sent in for diagnostic procedures in a tertiary hospital in the Netherlands. From a total of 10,645 samples obtained from 6175 patients, 20 samples from 11 patients (0.18%) tested positive for HPeV by RT-PCR. Two patients were positive for HPeV-1, two for HPeV-3, and one for HPeV-6. Six HPeVs could not be typed. Eight of the 11 HPeV-positive patients were immunocompromised. Due to comorbidity, we were unable to attribute the patients' clinical symptoms to the HPeV infection. The HPeV prevalence in adults found in this study is low compared to HPeV prevalence in children. This may be largely explained by the high seropositivity rates in adults, although there could be other mechanisms involved.
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Brouwer et al. (2020) conducted an observational in Suspected viral infection (n=6,175). Human parechovirus (HPeV) exposure was evaluated on HPeV prevalence.
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