Key result
HPeV-2 and HPeV-3 infections were associated with a 100% rate of viremia or sepsis upon admission, compared to 0% in HPeV-1 infected children.
Observational (n=28)
No
Absolute Event Rate: 100% vs 0%
p-value: p=0.001
A newly developed RT-PCR assay successfully identified and characterized Canadian HPeV isolates, revealing distinct clinical presentations and severity for different viral types primarily in young children.
May indicate higher sepsis risk with HPeV-2/3 in children; leaves open confirmation in prospective studies.
A new reverse transcription-polymerase chain reaction assay was developed for identification of 28 Canadian human parechovirus (HPeV) isolates, including 20 HPeV-1, 3 HPeV-2, and 5 HPeV-3, recovered from 1985 to 2004. All HPeV-1 isolates but 1 were genetically distinct from the Harris reference strain. One HPeV-2 isolate was related to the Williamson strain; the other 2 were related to the Connecticut strain. HPeV-3 isolates clustered together. Seventy-five percent of isolates were recovered during the typical enterovirus season. All patients but 1 were children with a mean age of 14.6 months, 6.3 months, and 0.7 months for HPeV-1, HPeV-2, and HPeV-3 patients, respectively. All HPeV-2- and HPeV-3-infected children were hospitalized with a diagnosis of viremia or sepsis. HPeV-1- infected children had bronchiolitis diagnosed in 50% of the cases, with few cases of pneumonia and enteritis. Two infected patients (1 child with leukemia and a 78-year-old woman) died of septic shock and severe pneumonia, respectively.
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Abed et al. (2006) conducted an observational in Human parechovirus (HPeV) infection (n=28). HPeV-2 and HPeV-3 infections vs. HPeV-1 infection was evaluated on Diagnosis of viremia or sepsis (p=0.001). HPeV-2 and HPeV-3 infections were associated with a 100% rate of viremia or sepsis upon admission, compared to 0% in HPeV-1 infected children.
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