Key result
Human Parechoviruses are nonenveloped RNA picornoviruses with at least 14 identified types, originally classified as enteroviruses before genomic sequencing in 1999.
Provides a historical overview of the discovery and classification of Human Parechoviruses.
HPeV awareness may prompt targeted testing in infants; leaves open optimal diagnostic and management strategies pending higher-level evidence.
HISTORICAL BACKGROUND HPeV are nonenveloped, positive-sense, single-stranded RNA picornoviruses that were first detected in 1956 in children with diarrhea. HPeV-1 and HPeV-2 were originally believed to belong to the genus Enterovirus (EV) and were named echoviruses 22 and 23 (1). In 1999, HPeV were assigned their genus name when genomic sequencing proved that they were not EV. At least 14 other HPeV types have been identified (Table 1) (2-34), starting with HPeV-3, which was initially reported in Japan in 2004 (21) and next reported in Canada in 2005 (35). Recombination between HPeV types may occur (31).
No takes yet. Share an insight, caveat, or question.
Shah et al. (2014) conducted a review in Human Parechovirus (HPeV). Human Parechoviruses are nonenveloped RNA picornoviruses with at least 14 identified types, originally classified as enteroviruses before genomic sequencing in 1999.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: