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December 13, 2007Journal of Clinical MicrobiologyOpen Access

Human Parechovirus Type 1, 3, 4, 5, and 6 Detection in Picornavirus Cultures

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Population

Picornavirus cultures that could not be typed in neutralization assays

Design

Preclinical

Authors

MVMichèl de VriesWesterdijk Fungal Biodiversity InstituteKPKrzysztof PyrćJagiellonian UniversityRBRon J. M. BerkhoutLeiden University Medical Center

Discussion

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Implication

VIDISCA may aid detection of rare HPeVs missed by standard PCR; hypothesis-generating in animal models, requiring human validation before clinical use.

Structured PICO

P
Population
Picornavirus cultures that could not be typed in neutralization assays
I
Intervention
VP1 reverse transcription-PCR (RT-PCR) and a virus discovery tool (VIDISCA)
O
Outcome
Detection of Human parechoviruses (HPeVs)

VIDISCA can identify uncommon human parechovirus isolates in untypable picornavirus cultures that may be missed by standard VP1 RT-PCR.

Cite This Study

Vries et al. (2007) studied this question.

synapsesocial.com/papers/6a8a7e3d451a22fc7efb9797https://doi.org/10.1128/jcm.02009-07
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Classic and Molecular Approaches for the Identification of Untypeable Enteroviruses2000 · 339 citations
  2. 2A distinct picornavirus group identified by sequence analysis.1992 · 278 citations
  3. 3Fourth Human Parechovirus Serotype2006 · 140 citations
  4. 4Isolation and Characterization of Novel Human Parechovirus from Clinical Samples2007 · 154 citations
  5. 5Analysis of a New Human Parechovirus Allows the Definition of Parechovirus Types and the Identification of RNA Structural Domains2006 · 140 citations