Key result
High Parechovirus A3 neutralizing antibody seropositivity was observed across Australia, the Netherlands, and the United States, with an overall seroprevalence of 68.9%, indicating widespread global circulation.
Why the study?
Recent PeV-A3 outbreaks in Australia suggested lower population immunity compared with regions having endemic PeV-A3 circulation.
Cross-Sectional (n=1,288)
Yes
The study demonstrates widespread circulation of parechovirus A3 across multiple continents, challenging the hypothesis of lower population immunity in Australia.
Recent parechovirus A3 (PeV-A3) outbreaks in Australia suggest lower population immunity compared with regions that have endemic PeV-A3 circulation. A serosurvey among populations in the Netherlands, the United States, and Australia before and after the 2013 Australia outbreak showed high PeV-A3 neutralizing antibody prevalence across all regions and time periods, indicating widespread circulation.
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Karelehto et al. (2018) conducted a cross-sectional in Parechovirus A3 (PeV-A3) Immunity (n=1,288). Geographic location and time period vs. Different geographic locations and time periods was evaluated on Parechovirus A3 neutralizing antibody (nAb) seropositivity (titer >1:8). High Parechovirus A3 neutralizing antibody seropositivity was observed across Australia, the Netherlands, and the United States, with an overall seroprevalence of 68.9%, indicating widespread global circulation.
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