Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A

In the palm of your hand: Total syntheses of the originally proposed and revised structures of the marine antitumor agent palmerolide A (see picture, originally proposed structure had opposite configurations at the positions indicated in red) were accomplished through a modular strategy that features a ring-closing metathesis to stereoselectively form the C8C9 bond and concurrently form the macrocycle.