Trimethylsilyl cyanide (TMS-CN) enantioselectively reacts with aldehydes to afford the corresponding cyanohydrin trimethylsilyl ethers in good yields in the presence of a chiral tin(II) Lewis acid prepared from 1,1′-dimethylstannocene, triflic acid and (+)-cinchonine.
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Kobayashi et al. (1991) studied this question.
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