Key result
High hypoxic burden was significantly associated with daytime systolic blood pressure elevation in patients with obstructive sleep apnea (adjusted B=6.04 mmHg; 95% CI 0.02-12.06; p=0.049).
Why the study?
OSA is an independent risk factor for hypertension, and hypoxic burden provides a more comprehensive measure of OSA severity than AHI, motivating an evaluation of its association with blood pressure.
Does high hypoxic burden associate with elevated daytime systolic blood pressure in patients with obstructive sleep apnea?
Observational (n=129)
Does high hypoxic burden associate with elevated daytime systolic blood pressure in patients with obstructive sleep apnea?
Mean Difference: 6.04 (95% CI 0.02–12.06)
p-value: p=0.049
High hypoxic burden is an independent risk factor for daytime systolic blood pressure elevation in patients with obstructive sleep apnea, outperforming the traditional apnea-hypopnea index.
Objectives Obstructive sleep apnea (OSA) is an independent risk factor for hypertension. Hypoxic burden (HB) is a more comprehensive indicator of OSA severity than apnea-hypopnea index (AHI), and this study aims to evaluate the association between HB and blood pressure in patients with OSA. Methods A total of 129 subjects diagnosed with OSA by polysomnography and completed 24-h ambulate blood pressure monitoring (ABPM) were prospectively recruited. According to the median HB, the patients were divided into high and low groups. Linear regression analyses were performed to investigate the association between 24-h mean systolic blood pressure (SBP) and other ABPM parameters with HB or AHI. Results In univariate linear regression analysis, high HB was identified as a significant risk factor for daytime SBP elevation (B=4.96, 95 % CI=2.57–7.35 mmHg, p=0.04). After adjustment, high HB was still significantly associated with daytime SBP elevation (B=6.04, 95 % CI=0.02–12.06 mmHg, p=0.049). Subgroup analyses further revealed that this association was more pronounced in female, aged ≥45 years, and overweight populations. However, there was no significant differences between AHI and all ABPM parameters. Conclusions Higher HB is as an independent risk factor for daytime SBP elevation in patients with OSA.
No takes yet. Share an insight, caveat, or question.
Zhuang et al. (2025) conducted an observational in Obstructive sleep apnea (n=129). High hypoxic burden vs. Low hypoxic burden was evaluated on Daytime systolic blood pressure (SBP) elevation (B 6.04, 95% CI 0.02-12.06, p=0.049). High hypoxic burden was significantly associated with daytime systolic blood pressure elevation in patients with obstructive sleep apnea (adjusted B=6.04 mmHg; 95% CI 0.02-12.06; p=0.049).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: