Key result
Baseline hemoglobin > 10 to <= 13 g/dL was associated with an approximately twofold greater risk of transfusion compared to hemoglobin > 13 g/dL in placebo-treated orthopedic surgery patients.
Why the study?
Does baseline hemoglobin concentration predict transfusion risk, and does Epoetin alfa reduce this risk in orthopedic surgery patients?
Population
276 orthopedic surgical patients (retrospective cohort) and an unspecified prospective validation cohort
Comparison
Epoetin alfa daily vs Placebo
Design
Cohort
Authors
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May aid preoperative transfusion risk stratification in orthopedic surgery; leaves open Epoetin alfa benefit pending randomized confirmation.
Observational (n=276)
Does baseline hemoglobin concentration predict transfusion risk, and does Epoetin alfa reduce this risk in orthopedic surgery patients?
Effect estimate: approximately twofold greater risk
Baseline hemoglobin is a strong predictor of transfusion risk in orthopedic surgery, and Epoetin alfa reduces this risk in patients with baseline hemoglobin between 10 and 13 g/dL.
Faris et al. (1999) conducted an observational in Orthopedic surgery (n=276). Baseline hemoglobin concentration > 10 to <= 13 g/dL vs. Hemoglobin > 13 g/dL was evaluated on Transfusion risk (approximately twofold greater risk). Baseline hemoglobin > 10 to <= 13 g/dL was associated with an approximately twofold greater risk of transfusion compared to hemoglobin > 13 g/dL in placebo-treated orthopedic surgery patients.
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