The existence of a specific abnormality of lipid metabolism in patients with atherosclerosis has been suggested by recent studies which have shown that the concentration of certain serum lipo- proteins in patients with coronary disease is sta- tistically different from that found in "normal" individuals. Gofman and his co-workers (1) found in such patients an elevation of a beta lipo- protein sub-fraction defined by ultracentrifugal flotation rates between Sf 10 and 20. Russ, Eder, and Barr (2, 3) measured the cholesterol content of precipitated serum lipoprotein fractions and found that the total beta lipoprotein fraction was increased in serum from a group of atherosclerotic patients as compared to a control group made up largely of hospital personnel. Similar results have been obtained by Nikkila (4), who measured the cholesterol content of electrophoretically separated protein fractions, and by Antonini et al. (
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Jencks et al. (1956) studied this question.
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