Lipoprotein patterns in experimentally induced hyperlipemic rabbits closely resemble those found in human hyperlipemic disorders, supporting the use of these animal models for studying lipid deposition in atherosclerosis.
Supports rabbit hyperlipidemia models for atherosclerosis research; leaves open translation to human clinical practice.
SUMMARY The lipoproteins in the plasma of human subjects with various naturally‐occurring hyperlipæmic disorders and in the plasma of rabbits with experimentally‐induced hyperlipæmic states were separated in a preparative ultracentrifuge at densities of 1.019, 1.063 and 1.200, and the composition of each of these classes determined by chemical analysis. The results showed that certain physical and chemical characteristics of the plasma lipoproteins in cases of human hypercholesterolæmia closely resembled those of the lipoproteins in the plasma of cholesterol‐fed rabbits. The lipoprotein patterns in cases of human hypertriglyceridæmia were also similar to those in hypertriglyceridæmic states induced by the administration of Triton WR1339 or cortisone to rabbits fed a normal diet or a diet to which cholesterol was added. The possible significance of these and other experiments in animals in an understanding of lipid deposition in the human atherosclerotic lesion is briefly discussed.
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Garlick et al. (1965) studied this question.
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