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The human potassium channel heag2, cloned from foetal brain, is a non-inactivating outward rectifier with different activation kinetics and lower terfenadine sensitivity compared to heag1.
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The study successfully cloned and characterized the human eag2 potassium channel, demonstrating distinct electrophysiological properties and lower terfenadine sensitivity compared to heag1.
We report the molecular cloning from foetal brain of the human potassium channel heag2. The cDNA encodes a protein of 988 amino acids, 73% identical to heag1. Heag2 is expressed in the brain, but is also found in a range of tissues including skeletal muscle. In oocytes, the channel is a non-inactivating outward rectifier, with dependence of activation rate on holding potential. Compared with heag1, the conductance-voltage curve for heag2 was shifted to the left, the voltage sensitivity was less, activation kinetics were different, and the sensitivity to terfenadine was lower. The heag2 channel may have important physiological roles.
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Ju et al. (2002) studied this question. heag2 potassium channel vs. heag1 was evaluated on Electrophysiological properties and tissue expression. The human potassium channel heag2, cloned from foetal brain, is a non-inactivating outward rectifier with different activation kinetics and lower terfenadine sensitivity compared to heag1.
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