Key result
Transcutaneous vascular ultrasound assessment of endothelial function in hypercholesterolaemic rabbits correlated highly with vasoreactivity of isolated vessels in an organ bath (r2=0.68).
Why the study?
Does in vivo transcutaneous vascular ultrasound accurately assess endothelial function compared to ex vivo organ bath in hypercholesterolaemic rabbits?
Does in vivo transcutaneous vascular ultrasound accurately assess endothelial function compared to ex vivo organ bath in hypercholesterolaemic rabbits?
Effect estimate: r(2)=0.68
Transcutaneous vascular ultrasound is a valid, non-invasive method for evaluating endothelial function in rabbit models of atherosclerosis, correlating well with traditional ex vivo methods.
Supports non-invasive endothelial assessment in hypercholesterolaemic rabbits; leaves open translation to clinical use.
Measurement of endothelial function in patients with atherosclerosis and lipid disorders is an important tool for the risk evaluation of a cardiovascular event, such as acute myocardial infarction and stroke. The feasibility of measuring endothelial function non-invasively in animal models has been limited so far. Therefore, we compared the assessment of endothelial function by in vivo transcutaneous vascular ultrasound (TVU) with the classical method of ex vivo organ bath, using the carotid artery of hypercholesterolaemic and normocholesterolaemic rabbits. The assessments of endothelial function by both techniques were performed on the same segments of the carotid artery. Vascular ultrasound detected impaired endothelium-dependent vasorelaxation induced by acetylcholine in the common carotid artery of hypercholesterolaemic rabbits. These results strongly correlated with measurements of endothelial function of isolated carotid artery rings. Furthermore, atherogenic diet caused significant fatty streak formation in the aorta, as well as significant increase of C-reactive protein and cholesterol levels. Endothelial function, an early marker of cardiovascular risk, could be non-invasively assessed and graded by TVU measurements. It correlated highly with vasoreactivity of isolated vessels in an organ bath (r(2)=0.68). We conclude that vascular ultrasound in hypercholesterolaemic rabbits is a valid method for evaluating endothelial function associated with atherosclerosis.
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Hiss et al. (2006) studied Hypercholesterolaemia. Transcutaneous vascular ultrasound (TVU) vs. Ex vivo organ bath was evaluated on Correlation of endothelial function assessment between TVU and isolated vessels in an organ bath (r(2)=0.68). Transcutaneous vascular ultrasound assessment of endothelial function in hypercholesterolaemic rabbits correlated highly with vasoreactivity of isolated vessels in an organ bath (r2=0.68).
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