Key result
Experimental Trypanosoma evansi infection in rats altered cardiac energy metabolism enzymes, including increased LDH and CK activities and decreased respiratory chain complex activities.
Trypanosoma evansi infection in rats alters cardiac energy metabolism enzymes and increases biomarkers of cardiac function, suggesting a role in disease pathogenesis.
May implicate cardiac metabolic disruption in T. evansi pathogenesis in rats; hypothesis-generating, with no direct clinical implications.
The aim of this study was to investigate the activities of important enzymes involved in the phosphoryl transfer network (adenylate kinase and creatine kinase (CK)), lactate dehydrogenase (LDH), respiratory chain complexes and biomarkers of cardiac function in rat experimentally infected by Trypanosoma evansi. Rat heart samples were evaluated at 5 and 15 days post-infection (PI). At 5 day PI, there was an increase in LDH and CK activities, and a decrease in respiratory chain complexes II, IV and succinate dehydrogenase activities. In addition, on day 15 PI, a decrease in the respiratory chain complex IV activity was observed. Biomarkers of cardiac function were higher in infected animals on days 5 and 15 PI. Considering the importance of the energy metabolism for heart function, it is possible that the changes in the enzymatic activities involved in the cardiac phosphotransfer network and the decrease in respiratory chain might be involved partially in the role of biomarkers of cardiac function of T. evansi-infected rats.
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Baldissera et al. (2015) studied Trypanosoma evansi infection. Trypanosoma evansi infection vs. Uninfected rats was evaluated on Activities of enzymes involved in phosphoryl transfer network, LDH, respiratory chain complexes, and biomarkers of cardiac function. Experimental Trypanosoma evansi infection in rats altered cardiac energy metabolism enzymes, including increased LDH and CK activities and decreased respiratory chain complex activities.
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