Key result
In diabetic rats, myocardial CK MB and BB decreased by 62% and 52%, whereas they increased in hereditary and catecholamine cardiomyopathy models, indicating differing metabolic adaptations.
Population
Diabetic rats, Bio 14.6 hamsters, and rats injected with isoprenaline, along with age-matched intact control…
Comparison
Induction of diabetic, hereditary, or… vs Age-matched intact control animals.
Design
Preclinical
Follow-up
Up to 8 weeks for diabetic rats, 240 days for hamsters…
Authors
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Isoenzyme shifts in diabetic rat hearts may refine necrosis markers; leaves open translation to human diabetic cardiomyopathy diagnosis.
Decreased myocardial CK and CK MB activity in the diabetic heart may lead to underestimation of enzymatically assessed infarct size.
Awaji et al. (1990) studied Diabetic, hereditary, and catecholamine cardiomyopathies. Diabetic, hereditary, and catecholamine cardiomyopathy models vs. Age-matched intact animals was evaluated on Myocardial isoenzyme activity of creatine kinase (CK), lactate dehydrogenase (LD) and aspartate aminotransferase (AST). In diabetic rats, myocardial CK MB and BB decreased by 62% and 52%, whereas they increased in hereditary and catecholamine cardiomyopathy models, indicating differing metabolic adaptations.
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