Key result
Experimental diabetes in rats decreased total cardiac creatine kinase activity by 35% and CK-M mRNA by 61.1%, which were restored by chronic insulin therapy.
Why the study?
Does chronic insulin therapy restore creatine kinase enzyme activity and mRNA levels in the hearts of diabetic rats?
Population
Normal, diabetic, and insulin-treated diabetic rats
Comparison
Chronic insulin therapy for 1 month vs Untreated diabetic rats and normal rats
Design
Preclinical
Follow-up
1 month
Authors
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May link reduced CK activity to contractile impairment in diabetic rat hearts; leaves open relevance to human diabetic cardiomyopathy.
Does chronic insulin therapy restore creatine kinase enzyme activity and mRNA levels in the hearts of diabetic rats?
Diabetes-induced decreases in creatine kinase enzyme activity and mRNA levels in the rat heart are restored by insulin therapy, suggesting a mechanism for diabetic cardiomyopathy.
Popovich et al. (1989) studied Experimental diabetes mellitus. Experimental diabetes mellitus vs. Normal rats was evaluated on Creatine kinase (CK) enzyme activity and CK-M mRNA level. Experimental diabetes in rats decreased total cardiac creatine kinase activity by 35% and CK-M mRNA by 61.1%, which were restored by chronic insulin therapy.
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