Why the study?
Does an impaired creatine kinase/phosphocreatine system contribute to contractile dysfunction in diabetic cardiomyopathy?
Population
Streptozotocin-induced diabetic rat hearts and control rat hearts
Comparison
Streptozotocin-induced diabetes vs Control rat hearts
Design
Preclinical
Authors
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Hypothesis-generating for CK impairment driving diabetic cardiomyopathy dysfunction; leaves open human translation and therapeutic targeting.
Does an impaired creatine kinase/phosphocreatine system contribute to contractile dysfunction in diabetic cardiomyopathy?
Impaired creatine kinase/phosphocreatine system kinetics contribute to contractile dysfunction at high workloads in diabetic cardiomyopathy.
Matsumoto et al. (1995) studied this question.
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