Key result
A genomewide meta-analysis identified several loci associated with circulating IGF-I and IGFBP-3 concentrations, including known (FOXO3) and novel (ASXL2) longevity-associated variants.
Meta-Analysis (n=30,884)
Yes
This genomewide meta-analysis identifies genetic loci associated with IGF-I and IGFBP-3 levels, providing insights into the genetic basis of the IGF axis and its potential role in longevity and age-related traits.
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No immediate change to IGF axis clinical practice; extends genetic links between longevity variants and circulating IGF-I/IGFBP-3.
Teumer et al. (2016) reported a meta-analysis. Genetic loci associated with IGF-I and IGFBP-3 was evaluated on Circulating IGF-I and IGFBP-3 concentrations. A genomewide meta-analysis identified several loci associated with circulating IGF-I and IGFBP-3 concentrations, including known (FOXO3) and novel (ASXL2) longevity-associated variants.
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