Key result
The relative contribution of nitric oxide and NO synthase-independent repolarization to acetylcholine-evoked relaxation in rat mesenteric arteries depends on the pre-contracting agonist.
Population
rat isolated mesenteric resistance arteries
Comparison
acetylcholine vs different pre-contractile agonists
Design
Preclinical
Authors
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Agonist-specific endothelial mechanisms in rat arteries are hypothesis-generating; leaves open human translation and clinical relevance.
The mechanism of endothelium-dependent relaxation in rat mesenteric arteries is determined by the specific contractile agonist used for pre-contraction.
Plane et al. (1996) studied Rat isolated mesenteric artery. Contractile agonists (Noradrenaline vs U46619) was evaluated on Mechanism of endothelium-dependent relaxation to acetylcholine. The relative contribution of nitric oxide and NO synthase-independent repolarization to acetylcholine-evoked relaxation in rat mesenteric arteries depends on the pre-contracting agonist.
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