April 1, 1992The Journal of Clinical Endocrinology & Metabolism

Characterization of urinary insulin-like growth factor binding proteins

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Population

Normal individuals and patients with renal disease

Design

Cross-sectional

Authors

YHYuta HasegawaHokkaido University of Science PCPieter A. CohenCambridge Health Alliance PYPeter D. YorginRady Children's Hospital-San Diego

Discussion

Member takes

Implication

May support urinary IGFBPs as markers for glomerular disease and renal failure; leaves open validation in prospective cohorts.

Structured PICO

Population

Normal individuals and patients with renal disease (glomerular disease with proteinuria, or renal failure with increased urinary beta-2-microglobulin)

Outcome

Presence and characterization of insulin-like growth factor binding proteins (IGFBPs) in urinesurrogate

Urinary IGFBPs are present in normal urine and their profiles are altered in specific renal diseases, suggesting potential utility as clinical markers.

Limitations

Additional studies are required before the origin of urinary IGFBPs in both normal and pathological conditions will be definitively established.

Cite This Study

Hasegawa et al. (1992) studied this question.

synapsesocial.com/papers/6a94d66595cf49f4209e56d6 https://doi.org/10.1210/jcem.74.4.1372323

View Full Paper

Ask AI

Bookmark

Characterization of urinary insulin-like growth factor binding proteins

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Characterization of urinary insulin-like growth factor binding proteins

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider