March 1, 2000The Journal of Clinical Endocrinology & MetabolismOpen Access

Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 Is Increased in Urine from Patients with Diabetic Nephropathy*

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Structured PICO

Population

57 subjects, including 34 patients with noninsulin-dependent diabetes mellitus (NIDDM), 14 patients with insulin-dependent diabetes mellitus (IDDM), and 9 controls, stratified by albumin excretion rate (normo-, micro-, and macroalbuminuria).

Comparator

Healthy controls and normoalbuminuric diabetic patients

Outcome

Urinary IGFBP-3 proteolysis and protease activitysurrogate

Diabetic nephropathy is associated with increased urinary IGFBP-3 proteolysis, which may increase local IGF bioavailability and contribute to structural kidney changes.

Discussion

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Implication

Supports IGF system involvement in diabetic nephropathy; hypothesis-generating, needs longitudinal studies before any clinical role.

Cite This Study

Shinada et al. (2000) studied this question.

synapsesocial.com/papers/6a71c36b6ceb2bbd16e039d0 https://doi.org/10.1210/jcem.85.3.6486

View Full Paper

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Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 Is Increased in Urine from Patients with Diabetic Nephropathy*

Structured PICO

Discussion

Implication

Cite This Study

Proteolysis of Insulin-Like Growth Factor-Binding Protein-3 Is Increased in Urine from Patients with Diabetic Nephropathy*

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider