August 1, 1995The Journal of Clinical Endocrinology & Metabolism

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity.

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Why the study?

Does insulin therapy reduce serum IGFBP-3 protease activity in children with insulin-dependent diabetes mellitus?

Population

Children with untreated insulin-dependent diabetes mellitus (IDDM)

Comparison

Insulin therapy vs Age-matched control pool and baseline…

Design

Cohort

Follow-up

1 month

Authors

ABAbdullah BereketMarmara University CLCharles H. LangPenn State Milton S. Hershey Medical Center SBSandra L. BlethenUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Insulin initiation was associated with normalized IGFBP-3 protease activity in pediatric IDDM; supports regulatory role but hypothesis-generating pending randomized confirmation.

Structured PICO

Does insulin therapy reduce serum IGFBP-3 protease activity in children with insulin-dependent diabetes mellitus?

Population

Children with untreated insulin-dependent diabetes mellitus (IDDM)

Intervention

Insulin therapy

Comparator

Age-matched control pool and baseline pre-treatment values

Outcome

Serum IGFBP-3 proteolysis and protease activitysurrogate

Insulin therapy in children with IDDM normalizes the initially elevated IGFBP-3 protease activity, suggesting insulin regulates this process.

Cite This Study

Bereket et al. (1995) studied this question.

synapsesocial.com/papers/6a94d5baa15fb1352cb2c112 https://doi.org/10.1210/jcem.80.8.7543110

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Implication

Insulin initiation was associated with normalized IGFBP-3 protease activity in pediatric IDDM; supports regulatory role but hypothesis-generating pending randomized confirmation.

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider