May 1, 2001The Journal of Clinical Endocrinology & MetabolismOpen Access

Use of the Ligand Immunofunctional Assay for Human Insulin-Like Growth Factor (IGF) Binding Protein-3 (IGFBP-3) to Analyze IGFBP-3 Proteolysis and IGF-I Bioavailability in Healthy Adults, GH-Deficient and Acromegalic Patients, and Diabetics1

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Population

194 adults including 36 healthy subjects, 23 hypopituitary patients untreated with GH, 43 acromegalics, 42…

Design

Cross-sectional

Authors

CLC LassarreCentre de Recherche Saint-Antoine FDF DuronSorbonne Université MBM BinouxInserm

Discussion

Member takes

Implication

May support IGFBP-3 proteolysis in insulin deficiency adaptation; leaves open its role in GH secretion disorders.

Structured PICO

Population

194 adults including 36 healthy subjects, 23 hypopituitary patients untreated with GH, 43 acromegalics (13 untreated), 42 insulin-treated type 1 diabetics (IDDM), and 50 type 2 diabetics (NIDDM; 22 insulin-treated, 28 treated with sulfonylurea and/or metformin).

Outcome

Percentage of proteolyzed IGFBP-3 and IGF-I/intact IGFBP-3 ratiosurrogate

Regulation of IGF-I bioavailability by limited proteolysis of IGFBP-3 contributes to adaptation to insulin deficiency and/or resistance, but not to disturbances of GH secretion.

Cite This Study

Lassarre et al. (2001) studied this question.

synapsesocial.com/papers/6a79633c684c0941cf320f94 https://doi.org/10.1210/jcem.86.5.7467

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Use of the Ligand Immunofunctional Assay for Human Insulin-Like Growth Factor (IGF) Binding Protein-3 (IGFBP-3) to Analyze IGFBP-3 Proteolysis and IGF-I Bioavailability in Healthy Adults, GH-Deficient and Acromegalic Patients, and Diabetics1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use of the Ligand Immunofunctional Assay for Human Insulin-Like Growth Factor (IGF) Binding Protein-3 (IGFBP-3) to Analyze IGFBP-3 Proteolysis and IGF-I Bioavailability in Healthy Adults, GH-Deficient and Acromegalic Patients, and Diabetics1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider