Key result
Experimental infection with Trypanosoma cruzi strain Be78 caused greater destruction of atrial cardiac muscle (34% remaining) compared to strain Be62 (50% remaining) in dogs.
Population
Dogs experimentally infected with Trypanosoma cruzi (n=11)
Design
Preclinical
Authors
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Strain variation modulates atrial damage in canine Chagas model; leaves open relevance to human disease progression and arrhythmias.
Experimental Trypanosoma cruzi infection in dogs causes chronic myocarditis with significant fibrosis and adipose tissue replacement that varies by strain and likely contributes to electrocardiographic disturbances.
Caliari et al. (2002) studied Chronic canine chagasic cardiomyopathy (n=11). Trypanosoma cruzi infection (strains Be78 and Be62) was evaluated on Areas occupied by cardiac muscle, connective and adipose tissues in the right atrium. Experimental infection with Trypanosoma cruzi strain Be78 caused greater destruction of atrial cardiac muscle (34% remaining) compared to strain Be62 (50% remaining) in dogs.
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