Key result
Experimental infection with Trypanosoma cruzi in 13 dogs led to chronic cardiovascular abnormalities, including diastolic dysfunction (E and A mitral wave reversal 0.71±0.17) and 6 deaths.
Population
13 adult female dogs experimentally infected with Trypanosoma cruzi (Colombian strain) at chronic stage
Design
Preclinical
Authors
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Does not alter human Chagas management; supports canine T. cruzi model for future cardiomyopathy research.
Dogs experimentally infected with Trypanosoma cruzi develop chronic chagasic cardiomyopathy characterized by diastolic dysfunction, arrhythmias, and myocardial injury, serving as a useful experimental model.
Pascon et al. (2010) studied Chronic chagasic cardiomyopathy (n=13). Trypanosoma cruzi infection was evaluated on Cardiovascular abnormalities (electrocardiographic, echocardiographic, hematological and biochemical). Experimental infection with Trypanosoma cruzi in 13 dogs led to chronic cardiovascular abnormalities, including diastolic dysfunction (E and A mitral wave reversal 0.71±0.17) and 6 deaths.
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