Key result
Experimental infection of dogs with Trypanosoma cruzi successfully reproduced the acute and chronic cardiac forms of human Chagas' disease, establishing the dog as a suitable experimental model.
Population
64 out-bred young dogs
Design
Preclinical
Follow-up
up to 24-48 months
Authors
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Validates canine model for Chagas cardiomyopathy research; extends preclinical options but leaves human translation open.
The dog is a suitable experimental model for studying Chagas' disease, as it successfully reproduces the acute and chronic cardiac forms seen in human infections.
Lana et al. (1992) studied Chagas' disease (n=64). Trypanosoma cruzi infection (Be-62 and Be-78 strains) was evaluated on Reproducibility of diffuse fibrosing chronic chagasic cardiopathy. Experimental infection of dogs with Trypanosoma cruzi successfully reproduced the acute and chronic cardiac forms of human Chagas' disease, establishing the dog as a suitable experimental model.
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