Key result
Inoculation of Beagles with North American Trypanosoma cruzi isolates (Tc-W) caused chronic ventricular arrhythmias and decreased mean ejection fraction to 63% of control values.
Why the study?
Does inoculation with North American Trypanosoma cruzi isolates cause electrocardiographic and echocardiographic abnormalities in purebred Beagles?
Population
Purebred Beagles
Comparison
Inoculation with North American Trypanosoma… vs Control values / uninfected state
Design
Preclinical
Follow-up
Up to 170 days postinoculation
Authors
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Supports canine Chagas cardiomyopathy model; leaves open translation to human disease management.
Does inoculation with North American Trypanosoma cruzi isolates cause electrocardiographic and echocardiographic abnormalities in purebred Beagles?
Inoculation of dogs with North American Trypanosoma cruzi isolates (Tc-W) induces acute myocarditis that progresses to chronic ventricular arrhythmias and left ventricular dysfunction, serving as a model for Chagas cardiomyopathy.
Barr et al. (1992) studied Trypanosomiasis (Trypanosoma cruzi infection). Trypanosoma cruzi isolates (Tc-W) vs. Tc-D isolates / control values was evaluated on Electrocardiographic and echocardiographic features. Inoculation of Beagles with North American Trypanosoma cruzi isolates (Tc-W) caused chronic ventricular arrhythmias and decreased mean ejection fraction to 63% of control values.
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