Key result
Transferring the amino-terminal half of the measles virus fusion protein cysteine-rich region to canine distemper virus fusion protein resulted in fusion when coexpressed with MVH.
The amino-terminal half of the measles virus fusion protein cysteine-rich region is critical for fusion when coexpressed with the hemagglutinin glycoprotein.
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Highlights a determinant of paramyxovirus fusion specificity; leaves open its role in host range and requires in vivo validation.
Wild et al. (1994) studied Measles virus fusion. Transfer of the amino-terminal half of the MVF cysteine-rich region to CDVF vs. CDVF without transfer was evaluated on Capacity to give fusion when coexpressed with MVH. Transferring the amino-terminal half of the measles virus fusion protein cysteine-rich region to canine distemper virus fusion protein resulted in fusion when coexpressed with MVH.
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