Emphasizes that a thorough study of disease immunology and recognition of essential antigens must precede the development of inactivated virus vaccines.
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May support high-titer requirements for mucosal protection by inactivated vaccines; leaves open essential antigen mapping before development.
Summary. On the basis of experience use of polivirus and measles virus vaccines the principles of design and use of inactivated virus vaccines are discussed. It is emphasized that a thorough study of the immunology of a disease should precede attempts at development of vaccines against it. All antigens essential for production of protective immunity must first be recognized to make a meaningful attack on the technical problem of vaccine development possible. Results obtained with poliovirus vaccine indicate that inactivated prepatations may afford protection against implantaion and multiplication of the virus in the mucous membranes provided that sufficiently high titers of circulating antibodies can be established.
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Sven Gard (1975) studied this question.
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