September 1, 1973Infection and Immunity
Studies on the Mechanism of the Priming Effect of Interferon on Interferon Production by Cell Cultures Exposed to Poly(rI) · Poly(rC)
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Population
Primary rabbit kidney (PRK) and mouse L-929 cell cultures
Comparison
Pretreatment with homologous interferon followed… vs Pretreatment with control medium followed by…
Design
Preclinical
Authors
Discussion
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Implication
Interferon priming may boost antiviral induction in cell models; leaves open mechanism and requires in vivo validation before any clinical consideration.
Structured PICO
P
Population
Primary rabbit kidney (PRK) and mouse L-929 cell cultures
I
Intervention
Pretreatment with homologous interferon (100 U/ml for 16 h) followed by exposure to poly(rI)·poly(rC)
C
Comparator
Pretreatment with control medium (MEM plus 3% calf serum) followed by exposure to poly(rI)·poly(rC)
O
Outcome
Interferon productionsurrogate
The study demonstrates that interferon priming enhances subsequent interferon production induced by poly(rI)·poly(rC) in cell cultures, though the exact mechanism remains unresolved as it is not due to increased binding or protection from nucleases.
Cite This Study
Clercq et al. (1973) studied this question.
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