Mechanism of the Antiviral Activity Resulting from Sequential Administration of Complementary Homopolyribonucleotides to Cell Cultures
Population
Cell cultures
Comparison
Sequential administration of complementary… vs Simultaneous administration of double-stranded…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for optimized antiviral dosing; leaves open translation beyond preclinical models.
Structured PICO
P
Population
Cell cultures
I
Intervention
Sequential administration of complementary homopolyribonucleotides (poly(rI) and poly(rC))
C
Comparator
Simultaneous administration of double-stranded complex poly(rI) . poly(rC), noncomplementary homopolynucleotides, or control cells
O
Outcome
Antiviral activitysurrogate
Sequential administration of complementary homopolyribonucleotides poly(rI) and poly(rC) to cell cultures results in antiviral activity by reuniting at the cellular level.
Cite This Study
Clercq et al. (1972) studied this question.