Methimazole, Carbimazole, and Congenital Skin Defects

Brief Reports1 January 1987Methimazole, Carbimazole, and Congenital Skin DefectsCORNELIS P. VAN DIJKE, M.D., Ph.D., ROB J. HEYDENDAEL, M.D., MARTIN J. DE KLEINE, M.D.CORNELIS P. VAN DIJKE, M.D., Ph.D., ROB J. HEYDENDAEL, M.D., MARTIN J. DE KLEINE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperthyroidism during pregnancy generally is treated with antithyroid drugs. In their reviews of the literature, Burrow (1) and Cooper (2) have advised against the use of methimazole (thiamazole) in pregnant women with hyperthyroidism because two studies reported an association of the drug with congenital skin defects (aplasia cutis). In 1972, Milham and Elledge (3) briefly described the cases of 12 patients with congenital scalp defects and noted that in three cases, one of which included a pair of fraternal twins, the mother had taken methimazole during pregnancy. In 1975, Mujtaba and Burrow (4) reported data from their study on the...References1. BURROW G. The management of thyrotoxicosis in pregnancy. N Engl J Med. 1985;313:562-5. CrossrefMedlineGoogle Scholar2. COOPER D. Antithyroid drugs. N Engl J Med. 1984;311:1353-62. CrossrefMedlineGoogle Scholar3. MILHAM S and ELLEDGE W. Maternal methimazole and congenital defects in children. Teratology. 1972;5:125. CrossrefGoogle Scholar4. MUJTABA Q and BURROW G. Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole. Obstet Gynecol. 1975;46:282-6. MedlineGoogle Scholar5. BACHRACH L and BURROW G. Aplasia cutis congenita and methimazole [Letter]. Can Med Assoc J. 1984;130:1264. MedlineGoogle Scholar6. MANNINO F, JONES K, and BENIRSCHKE K. Congenital skin defects and fetus papyraceus. J Pediatr. 1977;91:559-64. CrossrefMedlineGoogle Scholar7. JANSSON R, DAHLBERG P, and LINDSTRÖM B. Comparative bioavailability of carbimazole and methimazole. Int J Clin Pharmacol Ther Toxicol. 1983;21:505-10. MedlineGoogle Scholar8. VANDENBROUCKE J. A shortcut method for the calculation of the 95 per cent confidence interval of the Standardized Mortality Ratio. Am J Epidemiol. 1982;115:303-4. CrossrefGoogle Scholar9. MOMOTANI N, ITO K, HAMADA N, BAN Y, NISHIKAWA Y, and MIMURA T. Maternal hyperthyroidism and congenital malformation in the offspring. Clin Endocrinol (Oxf). 1984;20:695-700. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CORNELIS P. VAN DIJKE, M.D., Ph.D.; ROB J. HEYDENDAEL, M.D.; MARTIN J. DE KLEINE, M.D.Affiliations: Netherlands Centre for Monitoring of Adverse Reactions to Drugs Leidschendam Carolus Hospital 's-Hertogenbosch University Hospital of Amsterdam Amsterdam the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGraves' DiseaseRecent Advances in Ester Synthesis by Multi-Component Reactions (MCRs): A ReviewPrimer on Graves' Disease: What the Ophthalmologist Should Know and DoGraves' diseaseTeratogen update: Antithyroid medicationsTreatment of Graves' hyperthyroidism with thionamides: a position paper on indications and safety in pregnancyEndocrine Diseases of PregnancyRiesgo prenatal en el hipertiroidismo. Artículo de revisión y serie de casosThyroid diseaseLow-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal miceThyroid and Parathyroid Diseases in PregnancyAplasie cutanée congénitale et antithyroïdiens de synthèse au cours de la grossesse : série de cas et revue de la littératureMaternal factors in the origin of infantile hypertrophic pyloric stenosis: A population-based case-control studyThe Impact of Maternal Thyrotoxicosis and Antithyroid Drug Exposure on Fetal/Neonatal Brain DevelopmentPregnancy outcome in women treated with methimazole or propylthiouracil during pregnancyThyroid diseases during pregnancy: A number of important issuesEvaluation of Developmental Toxicity of Propylthiouracil and MethimazoleDie Patientin mit SchilddrüsenerkrankungEndocrine Diseases of PregnancyPrevalence of Thyrotoxicosis, Antithyroid Medication Use, and Complications Among Pregnant Women in the United StatesCarbimazole embryopathy in a Chinese population: Case series and literature reviewMotherisk RoundsThyroid disorders in pregnancyPharmacologic treatment of hyperthyroidism during pregnancyPropylthiouracil Is Teratogenic in Murine EmbryosThyroid and Parathyroid Diseases in PregnancyAplasia Cutis Congenita and Other Anomalies Associated with Methimazole Exposure During PregnancyTeratogenic exposuresTherapy of Hyperthyroidism in Pregnancy and BreastfeedingToxicological considerations for antithyroid drugs in childrenGrade 1 microtia, wide anterior fontanel and novel type tracheo-esophageal fistula in methimazole embryopathyPossible association between hyperthyroidism in pregnant women and obstructive congenital abnormalities of urinary tract in their offspring – a population-based case–control studyThyroid DiseaseAplasia cutis congenita due to methimazol exposure within the first trimester of pregnancy: case reportThyroid and parathyroid surgery in pregnancyBirth defects observed with maternal carbimazole treatment: Six cases reported to Nice's Pharmacovigilance CenterWhat the Obstetrician/Gynecologist Should Know About Thyroid DisordersThyroid Function and Human Reproductive HealthUn nouveau phénotype possible d'embryopathie au carbimazole : à propos d'une observationDiagnosis and Treatment of Thyroid Disease During PregnancyPutting Propylthiouracil in PerspectiveThyroid Disease and PregnancyEndocrine Diseases of PregnancyCarbimazole embryopathy-bilateral choanal atresia and patent vitello-intestinal duct: A case report and review of literatureIsolierte ausgedehnte familiäre Aplasia cutis des SchädelsChronic Medical Conditions in PregnancyThyroid Disease in PregnancyAplasia cutis congenita with skull defect in a monozygotic twin after exposure to methimazole in uteroHyperthyroidismSubsection ReportsTherapy Insight: management of Graves' disease during pregnancyPropylthiouracil Versus Methimazole in Treatment of Graves' Disease During PregnancyThyroid and Parathyroid Diseases in PregnancyMethimazoleThyroid disease in pregnancyAplasia Cutis Congenita After Methimazole Exposure in UteroHyperthyroidism in pregnancyThyroid Disease During PregnancyOptimal Management of Hair Loss (Alopecia) in ChildrenTeratogenic drugs ??? part 2Aplasia Cutis Congenita and Dysmorphic Syndrome After Antithyroid Therapy During PregnancyTeratogen update: antithyroid drugs?methimazole, carbimazole, and propylthiouracilDisorders of hair in infants and children other than alopeciaThyroid disease in pregnancyEctodermal abnormalities associated with methimazole intrauterine exposureDrug Therapy for Hyperthyroidism in PregnancyHyperthyroidism in Pregnancy: Diagnosis and TreatmentFetal and Neonatal HyperthyroidismThe wide spectrum of clinical expression in Adams-Oliver syndrome: a report of two casesMethimazole embryopathy: Delineation of the phenotypeHYPERTHYROIDISM IN PREGNANCYANTITHYROID DRUGS FOR THE TREATMENT OF HYPERTHYROIDISM CAUSED BY GRAVES' DISEASEThyroid disorders and pregnancyMANAGEMENT OF THYROTOXICOSIS IN PREGNANCYTREATMENT OF THYROID DISEASE IN PREGNANCYHyperthyroidism in PregnancyAplasia cutis congenita after exposure to methimazole: a causal relationship?Thyroid Disorders of PregnancyManagement of Thyroid DisordersTHYROID DISEASE AND FERTILITYAplasia cutis congenita of the scalp in an infant exposed to valproic acid in uteroA comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancyA comparison of propylthiouracil versus methimazole in the treatment of hyperthyroidism in pregnancyReview of Antithyroid Drug Use During Pregnancy and Report of a Case of Aplasia CutisOrganization of Auditory Callosal Connections in Hypothyroid Adult RatsThyroid disease in pregnancyEndocrine Problems of Adolescent PregnancyPregnancy and the thyroidSpontaneous Monitoring of Adverse Reactions to Drugs, Procedures, and Experiences in the Netherlands10 Endocrine emergencies in pregnancyThyroid Disease and PregnancyReview Thyroid disease in relation to pregnancyEffects of thyroid antagonists on rat embryos cultured in vitroThyroid Diseases in PregnancyThyroid and antithyroid drugs 1 January 1987Volume 106, Issue 1Page: 60-61KeywordsAdverse reactionsDizygotic twinsDrugsHyperthyroidismPregnancyResearch designStatistical dataTherapeutic drug monitoring ePublished: 1 December 2008 Issue Published: 1 January 1987 PDF downloadLoading ...