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October 10, 2023International Journal Of Medical Science And Clinical Invention0 citationsOpen Access

The Relationship between the Angiographic Atherosclerotic Burden and the Inflammatory Factors in Diabetic and Non-Diabetic Patients with Coronary Artery Disease

Why the study?

Are inflammatory parameters (NHR, LHR, PHR) associated with angiographic atherosclerotic burden in diabetic and non-diabetic patients with coronary artery disease?

Population

418 patients with coronary artery disease who underwent coronary angiography, including 98 with type 2…

Design

Cohort

Key result

In patients with coronary artery disease, type 2 diabetes was associated with significantly higher atherosclerotic burden (mean SYNTAX score 18.5 vs 11.6) and elevated inflammatory markers compared to non-diabetic patients.

Authors

VTVeysel Tosun

Discussion

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Overview

NHR/LHR/PHR may correlate with CAD severity in diabetes; leaves open whether they improve risk stratification beyond standard markers.

Study Design

Type

Observational (n=418)

Multicenter

No

Structured PICO

Are inflammatory parameters (NHR, LHR, PHR) associated with angiographic atherosclerotic burden in diabetic and non-diabetic patients with coronary artery disease?

P
Population
418 patients with an initial diagnosis of coronary artery disease undergoing coronary angiography, including 98 with type 2 diabetes and 320 without diabetes.
C
Comparator
Non-diabetic patients with coronary artery disease
O
Outcome
Association between inflammatory parameters (neutrophil to HDL, lymphocyte to HDL, and platelet to HDL ratios) and angiographic atherosclerotic burden (SYNTAX and Gensini scores)surrogate

Inflammatory ratios involving HDL are elevated in diabetic patients with CAD and correlate with angiographic severity of atherosclerosis.

Main Result

Absolute Event Rate: 18.5% vs 11.6%

p-value: p=<0.001

Limitations

  • Relatively small sample size from a single center may have introduced bias
  • Status of long-term glycemic control in DM patients was not fully clear as HbA1c was only measured at baseline
  • Cardiovascular events and other diabetic vascular effects were not fully specified
  • Patients with DM had higher rates of hypertension and smoking, and were slightly older with higher BMI
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Cite This Study

Veysel Tosun (2023) conducted an observational in Coronary Artery Disease (n=418). Type 2 Diabetes Mellitus vs. Non-diabetic patients was evaluated on SYNTAX score (p=<0.001). In patients with coronary artery disease, type 2 diabetes was associated with significantly higher atherosclerotic burden (mean SYNTAX score 18.5 vs 11.6) and elevated inflammatory markers compared to non-diabetic patients.

synapsesocial.com/papers/6a94dca2b5639cad21767d60https://doi.org/10.18535/ijmsci/v10i10.01
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