Key result
Long-term amiodarone therapy caused multiorgan toxicity in a 73-year-old male, representing the first reported case of amiodarone-induced loculated pleural effusion without lung parenchymal involvement.
Case Report (n=1)
Long-term, high-dose amiodarone therapy can cause multiorgan toxicity, including the rare presentation of loculated pleural effusion without lung parenchymal involvement.
Alerts clinicians to rare amiodarone-related loculated effusions in multiorgan toxicity; extends known adverse effects but remains hypothesis-generating.
Amiodarone is an extremely effective antiarrhythmic drug that is known to cause many adverse effects such as pulmonary, thyroid, and liver toxicities. Of these, pulmonary toxicity is most serious. Pulmonary toxicity can present as interstitial pneumonitis, organizing pneumonia, pulmonary nodules and masses, and very rarely pleural effusions. We present a case of a 73-year-old male who presented with progressive exertional dyspnea, nonproductive cough, generalized fatigue, and weakness. He was found to have multiorgan toxicity secondary to long-term treatment with high doses of amiodarone. This case illustrates that amiodarone may cause toxicity involving multiple organs simultaneously in patients receiving long-term therapy and represents the first reported case of amiodarone-induced loculated pleural effusion without associated lung parenchymal involvement.
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Shaaban et al. (2017) conducted a case report in Amiodarone-induced loculated pleural effusion (n=1). Amiodarone was evaluated. Long-term amiodarone therapy caused multiorgan toxicity in a 73-year-old male, representing the first reported case of amiodarone-induced loculated pleural effusion without lung parenchymal involvement.
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