Key result
Patients with acute gastrointestinal bleeding had significantly lower platelet aggregation and P-selectin expression compared to healthy subjects (p≤0.05), partly related to drug use.
Why the study?
Is platelet function reduced in patients presenting with acute gastrointestinal bleeding compared to healthy controls and patients on antiplatelet therapy without bleeding?
Population
35 patients presenting with acute gastrointestinal bleeding (hematemesis or melena)
Design
Cross-sectional
Authors
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Suggests antiplatelet drugs contribute to platelet dysfunction in acute GI bleeding; leaves open whether testing improves risk stratification.
Observational (n=86)
Is platelet function reduced in patients presenting with acute gastrointestinal bleeding compared to healthy controls and patients on antiplatelet therapy without bleeding?
p-value: p=≤0.05
Platelet function is significantly reduced in patients with acute GI bleeding, with a considerable proportion related to antiplatelet drug use.
Kringen et al. (2010) conducted an observational in Acute gastrointestinal bleeding (n=86). Acute gastrointestinal bleeding vs. Healthy controls and patients on anti-platelet drugs without bleeding was evaluated on Platelet aggregation and P-selectin expression after arachidonic acid stimulation (p=≤0.05). Patients with acute gastrointestinal bleeding had significantly lower platelet aggregation and P-selectin expression compared to healthy subjects (p≤0.05), partly related to drug use.
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