Key result
Increasing the clopidogrel maintenance dose to 150 mg significantly reduced median residual platelet aggregation at 14 days compared to historic controls (10.0% vs 17.0%; P<0.001).
Why the study?
Does increasing the clopidogrel maintenance dose to 150 mg improve platelet inhibition in patients with insufficient response after elective PCI?
Cohort (n=174)
Does increasing the clopidogrel maintenance dose to 150 mg improve platelet inhibition in patients with insufficient response after elective PCI?
Absolute Event Rate: 10% vs 17%
p-value: p=<0.001
Increasing the clopidogrel maintenance dose to 150 mg significantly improves platelet inhibition in patients with a low initial response after elective PCI.
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Higher clopidogrel dose may improve platelet inhibition in low responders post-PCI; leaves open impact on clinical events.
Trenk et al. (2008) conducted a cohort in Elective coronary stent placement (n=174). Clopidogrel vs. Historic control (75 mg daily) was evaluated on Residual platelet aggregation (RPA) at 14 days (p=<0.001). Increasing the clopidogrel maintenance dose to 150 mg significantly reduced median residual platelet aggregation at 14 days compared to historic controls (10.0% vs 17.0%; P<0.001).
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