Key result
A 150 mg/day maintenance dose of clopidogrel significantly reduced 20 microM ADP-induced platelet aggregation compared to 75 mg/day in patients undergoing elective PCI (52.1% vs 64.0%; p<0.001).
Why the study?
Does a 150 mg/day maintenance dose of clopidogrel improve platelet inhibition compared to a 75 mg/day dose in patients undergoing elective PCI?
Population
40 patients undergoing elective percutaneous coronary intervention (PCI)
Comparison
Clopidogrel 150 mg/day maintenance dose for 30… vs Clopidogrel 75 mg/day maintenance dose for 30 days
Design
RCT, randomized
Follow-up
60 days
Authors
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Higher clopidogrel maintenance dosing enhances platelet inhibition in elective PCI; confirms dose-dependent effects in this RCT.
RCT (n=40)
randomized
Does a 150 mg/day maintenance dose of clopidogrel improve platelet inhibition compared to a 75 mg/day dose in patients undergoing elective PCI?
Absolute Event Rate: 52.1% vs 64%
p-value: p=<0.001
A 150 mg/day maintenance dose of clopidogrel significantly reduces platelet reactivity compared to the standard 75 mg/day dose in patients undergoing elective PCI.
Bernardo et al. (2007) conducted an RCT in Elective percutaneous coronary intervention (PCI) (n=40). Clopidogrel vs. 75 mg/day was evaluated on 20 microM ADP-induced platelet aggregation (p=<0.001). A 150 mg/day maintenance dose of clopidogrel significantly reduced 20 microM ADP-induced platelet aggregation compared to 75 mg/day in patients undergoing elective PCI (52.1% vs 64.0%; p<0.001).
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