Key result
Daily subcutaneous injection of T3 for 7 days increased UCP2 mRNA expression in BAT, WAT, and soleus muscle by 1.6-, 1.6-, and 1.7-fold, respectively, compared to controls in male rats.
Effect estimate: 1.6- to 1.7-fold increase
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T3 effects on UCP2 remain preclinical; leaves open relevance to human energy metabolism or cardiometabolic therapy.
Masaki et al. (1997) studied Hyperthyroid state. Triiodothyronine (T3) vs. Controls was evaluated on UCP2 mRNA expression in brown adipose tissue (BAT), white adipose tissue (WAT) and soleus muscle (1.6- to 1.7-fold increase). Daily subcutaneous injection of T3 for 7 days increased UCP2 mRNA expression in BAT, WAT, and soleus muscle by 1.6-, 1.6-, and 1.7-fold, respectively, compared to controls in male rats.
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