Key result
Fasting subcutaneous adipose UCP-2 expression inversely correlates with BMI and leptin.
Observational
Effect estimate: r = -0.45
p-value: p=0.026
UCP-2 expression in subcutaneous adipose tissue is inversely related to adiposity and local plasma leptin levels, suggesting a potential role in the pathogenesis of obesity.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for UCP-2 in obesity; requires longitudinal studies before any clinical relevance.
Pinkney et al. (2000) conducted an observational in Obesity. Adiposity vs. Lean individuals was evaluated on Correlation of UCP-2 expression with body mass index in the fasting state (r = -0.45, p=0.026). In the fasting state, UCP-2 expression in subcutaneous adipose tissue correlated inversely with body mass index (r = -0.45; P = 0.026) and leptin (r = -0.50; P = 0.018).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: