Key result
UCP1 and UCP3 gene expression contributed to lipid and carbohydrate oxidation in patients submitted to bariatric surgery, with UCP3 expression significantly associated with postoperative lipid oxidation (r2=0.640, p=0.01).
Why the study?
Does UCP1 and UCP3 expression influence substrate oxidation and body composition in women with grade III obesity undergoing bariatric surgery?
Observational (n=23)
No
Does UCP1 and UCP3 expression influence substrate oxidation and body composition in women with grade III obesity undergoing bariatric surgery?
Effect estimate: r2 = 0.640
p-value: p=0.01
UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation and body composition modulation in patients undergoing bariatric surgery.
UCP3 expression may aid understanding of post-bariatric metabolism; hypothesis-generating, requires prospective trials before any clinical role.
BACKGROUND/OBJECTIVE: Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These proteins participate in thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 and UCP3 expression influences substrate oxidation and elicits possible changes in body composition in patients submitted to bariatric surgery. SUBJECTS/METHODS: This is a longitudinal study comprising 13 women with obesity grade III that underwent bariatric surgery and 10 healthy weight individuals (control group). Body composition was assessed by bioelectrical impedance. Carbohydrate and fat oxidation was determined by indirect calorimetry. Subcutaneous adipose tissue was collected for gene expression analysis. QPCR was used to evaluate UCP1 and UCP3 expression. RESULTS: Obese patients and the control group differed significantly in terms of lipid and carbohydrate oxidation. Six months after bariatric surgery, the differences disappeared. Lipid oxidation correlated with the percentage of fat mass in the postoperative period. Multiple linear regression analysis showed that the UCP1 and UCP3 genes contributed to lipid and carbohydrate oxidation. Additionally, UCP3 expression was associated with BMI, percentage of lean body mass, and percentage of mass in the postoperative period. CONCLUSIONS: UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery. In addition, UCP3 participates in body composition modulation six months postoperatively.
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Oliveira et al. (2016) conducted an observational in Obesity grade III (n=23). Bariatric surgery (Roux-en-Y gastric bypass) vs. Preoperative baseline and healthy controls was evaluated on Contribution of UCP3 expression to lipid oxidation postoperatively (r2 = 0.640, p=0.01). UCP1 and UCP3 gene expression contributed to lipid and carbohydrate oxidation in patients submitted to bariatric surgery, with UCP3 expression significantly associated with postoperative lipid oxidation (r2=0.640, p=0.01).
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