Key result
Among 105 sudden deaths post-MI, recurrent MI or cardiac rupture accounted for a high proportion early on, whereas presumed arrhythmic death was more likely after 3 months (P<0.0001).
Observational (n=105)
p-value: p=<0.0001
Recurrent MI and cardiac rupture account for a high proportion of early sudden deaths post-MI, whereas arrhythmic deaths predominate after 3 months, potentially explaining the lack of benefit of early ICD implantation.
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Supports time-dependent post-MI sudden death mechanisms; leaves open optimal ICD timing for future trials.
Pouleur et al. (2010) conducted an observational in Myocardial Infarction with Left Ventricular Dysfunction or Heart Failure (n=105). Time elapsed since index myocardial infarction was evaluated on Probable cause of sudden death based on autopsy findings and its variation with time after MI (p=<0.0001). Among 105 sudden deaths post-MI, recurrent MI or cardiac rupture accounted for a high proportion early on, whereas presumed arrhythmic death was more likely after 3 months (P<0.0001).
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