Key result
One year of antihypertensive therapy in children with primary hypertension significantly decreased oxidative stress, with median TBARS concentrations falling from 0.56 to 0.25 μmol/l.
Why the study?
Does 1 year of antihypertensive therapy improve oxidative stress and target organ damage in children with primary hypertension?
Observational (n=86)
No
Does 1 year of antihypertensive therapy improve oxidative stress and target organ damage in children with primary hypertension?
Absolute Event Rate: 0.25% vs 0.56%
p-value: p=<0.001
In children with primary hypertension, oxidative stress correlates with target organ damage and metabolic abnormalities, and improves with antihypertensive therapy in association with metabolic improvements rather than blood pressure reduction.
Antihypertensive therapy may reduce oxidative stress in hypertensive children; leaves open effects on target organ damage.
BACKGROUND: The relation between primary hypertension (PH), target organ damage (TOD) and oxidative stress (SOX) is not known. METHODS: We assessed SOX in 86 children with PH before and after 12 months of standard non-pharmacological and pharmacological therapy based on renin-angiotensin system blockade. RESULTS: Patients with left ventricular hypertrophy (LVH) and with carotid intima-media thickness (cIMT) >2SDS had higher thiobarbituric acid reactive substances (TBARS) concentrations in comparison to patients without LVH or with normal cIMT. Patients with metabolic syndrome (MS) had lower activity of gluthatione peroxidase, higher asymmetric dimethyloarginine (ADMA) and oxidized LDL cholesterol (oxyLDL) in comparison to patients without MS. TBARS correlated with left ventricular concentric hypertrophy, cIMT, albuminuria and SBP/24 h. ADMA and oxyLDL correlated with CRP and TG/HDL ratio. After 1 year of antihypertensive treatment blood pressure, TOD and prevalence of MS decreased. TBARS decreased and glutathione concentrations increased. The decrease of TBARS concentration correlated with the decrease of body mass index (BMI). Decrease of oxyLDL and ADMA correlated with increased insulin sensitivity, however markers of SOX did not correlate with BP decrease. CONCLUSION: SOX in children with PH correlates with TOD, metabolic abnormalities, changes in fat amount and improvement of insulin sensitivity, but not with BP decrease.
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Śladowska-Kozłowska et al. (2012) conducted an observational in Primary hypertension (n=86). Antihypertensive therapy (lifestyle modifications and/or ACEi/ARB) vs. Baseline (pre-treatment) was evaluated on Thiobarbituric acid reactive substances (TBARS) concentration (μmol/l) (p=<0.001). One year of antihypertensive therapy in children with primary hypertension significantly decreased oxidative stress, with median TBARS concentrations falling from 0.56 to 0.25 μmol/l.
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