Key result
Plasma ADMA (0.23 vs 0.10 micromol/l) and SDMA (1.37 vs 1.18 micromol/l) concentrations were significantly higher in hypertensive children compared to normotensive controls.
Why the study?
Are elevated plasma concentrations of nitric oxide synthase inhibitors associated with hypertension in children and adolescents?
Population
47 children and adolescents, comprising 38 hypertensives and 9 healthy normotensive controls. Also included…
Comparison
Measurement of plasma concentrations of nitric… vs Healthy normotensive controls
Design
Case-control
Authors
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May link NOS inhibitors to pediatric hypertension; hypothesis-generating, needs prospective validation before any clinical role.
Case-Control (n=47)
Are elevated plasma concentrations of nitric oxide synthase inhibitors associated with hypertension in children and adolescents?
Elevated plasma levels of ADMA and SDMA are associated with hypertension in children and may play a role in its pathophysiology by altering vascular tone.
Goonasekera et al. (1997) conducted a case-control in Hypertension (n=47). Circulating nitric oxide synthase inhibitors (ADMA, SDMA, L-NMMA) vs. Healthy normotensive controls was evaluated on Plasma ADMA and SDMA concentrations. Plasma ADMA (0.23 vs 0.10 micromol/l) and SDMA (1.37 vs 1.18 micromol/l) concentrations were significantly higher in hypertensive children compared to normotensive controls.
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