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January 1, 1984Catheterization and Cardiovascular Diagnosis

Transcatheter laser dissolution of human atherosclerotic plaques: A model for testing catheters and techniques

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Why the study?

Does a balloon-tipped laser catheter create channels in obstructed human coronary arteries in a simulated physiologic model?

Population

2 obstructed human cadaver coronary artery segments and 4 normal dog femoral artery segments in a simulated…

Design

Preclinical

Authors

LGLawrence J. GessmanCooper Medical School of Rowan University CRCharles W. Reno VMVladir MaranhãoDeborah Heart and Lung Center

Discussion

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Implication

Perforation risk cautions against immediate translation; leaves open further preclinical testing of laser angioplasty.

Structured PICO

Does a balloon-tipped laser catheter create channels in obstructed human coronary arteries in a simulated physiologic model?

P

Population

2 obstructed human cadaver coronary artery segments and 4 normal dog femoral artery segments in a simulated physiologic model of the human arterial circulation

I

Intervention

Balloon-tipped catheter with a central 0.02-cm light fiber delivering 4 W of laser energy, flushed with saline

O

Outcome

Creation of channels in obstructed arteries and assessment of thermal tissue damagesurrogate

This preclinical model demonstrates the feasibility of laser angioplasty to create channels in obstructed coronary arteries, while highlighting the risk of perforation.

Limitations

Potential hazards of the procedure (perforation)
Need for laser catheters that are flexible and capable of precise alignment

Cite This Study

Gessman et al. (1984) studied this question.

synapsesocial.com/papers/6a94e655397e3dbeede612a1 https://doi.org/10.1002/ccd.1810100111

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