Why the study?
Laser-based treatments for atherosclerotic plaques have limited clinical use because of low plaque removal efficiency and a high risk of complications compared with other methods.
Does ultrasound-assisted laser ablation improve the removal of lipid deposition in atherosclerotic plaques compared to laser or ultrasound alone in preclinical models?
Population
Pig belly fat samples and human atherosclerotic plaque samples
Comparison
Ultrasound-assisted laser ablation vs laser-only and ultrasound-only controls
Design
Preclinical experimental feasibility study
Authors
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Demonstrates preclinical feasibility for laser atherectomy; leaves open clinical safety and efficacy before any practice change.
Does ultrasound-assisted laser ablation improve the removal of lipid deposition in atherosclerotic plaques compared to laser or ultrasound alone in preclinical models?
The addition of ultrasound to laser therapy effectively reduces the required laser power for atherosclerotic plaque removal in preclinical models, potentially improving the safety and efficiency of laser atherectomy.
Singh et al. (2023) studied this question.
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