What question did this study set out to answer?

To compare the kinetics, magnitude, and protective efficacy of secondary versus primary Th1 immune responses against airborne Mycobacterium tuberculosis challenge in mice.

June 13, 2005The Journal of Experimental MedicineOpen Access

Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice

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Authors

YJYu‐Jin JungCenters for Disease Control and Prevention LRLynn RyanRoyal Manchester Children's Hospital RLRonald LaCourseTrudeau Institute

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Implication

Experimental study demonstrates earlier but non-sterilizing Th1 responses to airborne Mycobacterium tuberculosis in mice, suggesting secondary immunity is not superior to primary responses.

Key Points

To compare the kinetics, magnitude, and protective efficacy of secondary versus primary Th1 immune responses against airborne Mycobacterium tuberculosis challenge in mice.
Compared immunized mice (cured of a primary pulmonary infection) with naive mice following airborne challenge with Mycobacterium tuberculosis.
Measured lung mRNA expression of Th1 cytokines and inducible nitric oxide synthase, monitored CD4 T-cell accumulation in pulmonary lesions, and assessed bacterial loads over time.
Immunized mice generated Th1 cytokine mRNA and inducible nitric oxide synthase expression several days earlier than naive mice, accompanied by accelerated accumulation of pathogen-specific CD4 Th1 cells in lung lesions.
Earlier immune induction in immunized mice inhibited bacterial replication when infection was at a 1-log lower level compared to naive controls.
Bacterial growth in both immunized and naive mice stabilized at a stationary level rather than resolving, demonstrating that secondary Th1 immunity is neither qualitatively nor quantitatively superior to primary immunity.

Cite This Study

Jung et al. (2005) studied this question.

synapsesocial.com/papers/6a94e689cd304312aafa5783 https://doi.org/10.1084/jem.20050265

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Implication

Experimental study demonstrates earlier but non-sterilizing Th1 responses to airborne Mycobacterium tuberculosis in mice, suggesting secondary immunity is not superior to primary responses.

Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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