Key result
High-sensitivity CRP at admission predicted worse in-hospital outcomes in acute myocardial infarction independently of the GRACE risk score.
Why the study?
Does hsCRP at admission predict in-hospital cardiac events in patients with acute myocardial infarction independently of the GRACE risk score?
Observational (n=98)
Does hsCRP at admission predict in-hospital cardiac events in patients with acute myocardial infarction independently of the GRACE risk score?
High-sensitivity CRP at admission predicts in-hospital cardiac events in AMI patients independently of the GRACE risk score, with a threshold of 1.45 mg/dL showing maximum likelihood.
Answers are grounded in this paper and cite their sources.
May aid AMI in-hospital prognostication beyond GRACE; hypothesis-generating and should not yet change practice.
High-sensitivity CRP (hsCRP) is being increasingly used as a marker for cardiac risk assessment and as a prognostic tool in acute coronary syndrome. We analyzed the relation between hsCRP values at admission and in-hospital outcomes in 98 consecutive patients with acute myocardial infarction (AMI) undergoing catheterization. Patients with cardiac events had more advanced Killip class, more proportion of depressed left ventricular ejection fraction (LVEF), higher Global Registry of Acute Coronary Events (GRACE) risk score, and higher hsCRP levels. High-sensitivity CRP and GRACE risk score showed a significant positive correlation (r = .320, P = .002). In multivariate analysis, hsCRP resulted as a predictor of worse in-hospital outcomes independently of GRACE risk score (OR 1.122, CI95%:1.005-1.252, P = .040). The hsCRP value showing the maximum likelihood ratio for predicting cardiac events was 1.45 mg/dL. High levels of hsCRP were also associated with development of contrast-induced nephropathy but not with bleeding events.
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Raposeiras‐Roubín et al. (2011) conducted an observational in Acute myocardial infarction (AMI) (n=98). High-sensitivity CRP (hsCRP) at admission was evaluated on Worse in-hospital outcomes (cardiac events) (OR 1.122, 95% CI 1.005-1.252, p=0.040). High-sensitivity CRP at admission predicted worse in-hospital outcomes in acute myocardial infarction independently of the GRACE risk score.
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