Key result
A 62-year-old woman with atrial fibrillation developed diffuse alveolar haemorrhage secondary to warfarin over-anticoagulation (INR >9), which was successfully treated with fresh frozen plasma, vitamin K, and mechanical ventilation.
Case Report (n=1)
Diffuse alveolar haemorrhage is a rare but potentially lethal complication of warfarin over-anticoagulation that requires early diagnosis and aggressive reversal therapy.
Rare warfarin complication in AF may warrant vigilant monitoring and prompt reversal; Level 5 case leaves open standardized protocols.
Alveolar haemorrhage is a rare and serious medical emergency with many causes. Diffuse alveolar haemorrhage due to warfarin therapy has been rarely reported in the literature. In this paper, we describe the case of 62-year-old woman with a history of chronic atrial fibrillation treated with warfarin, who was admitted to our institution with haemoptysis and dyspnoea. Alveolar haemorrhage was suspected clinically and subsequently confirmed by bronchoscopy. The patient required aggressive treatment with fresh frozen plasma, vitamin K and mechanical ventilation with a successful outcome. We emphasise the need for early diagnosis and fast therapeutic intervention, especially with over-anticoagulation (INR >9), in patients with this rare and potentially lethal condition.
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Waness et al. (2009) conducted a case report in Diffuse alveolar haemorrhage secondary to warfarin therapy for atrial fibrillation (n=1). Warfarin was evaluated. A 62-year-old woman with atrial fibrillation developed diffuse alveolar haemorrhage secondary to warfarin over-anticoagulation (INR >9), which was successfully treated with fresh frozen plasma, vitamin K, and mechanical ventilation.
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